BOB体育

Scientists Also Identify Potential BOB体育 That Could Reduce Key Mechanism of These Diseases

A new study by researchers at the University of Maryland School of BOB体育 (UM SOM) has found a link between some neurodegenerative diseases and a birth defect that occurs commonly in infants of women with diabetes. This is the first time this link has been identified; it may indicate a new way to understand, and perhaps treat, both the birth defects and the neurodegenerative diseases.

The findings were published recently in the .

Zhiyong Zhao, PhD, E. Albert Reece, MD, PhD, MBA, and Lixue Cao, PhD

鈥淭hese results were really surprising,鈥� said the study鈥檚 lead author, Zhiyong Zhao, PhD, an Associate Professor of the at UM SOM. 鈥淭he association suggests that these disparate diseases may have more in common than we previously realized.鈥� The researchers on the article also include UM SOM Dean , and Lixue Cao, PhD, a Postdoctoral Fellow in the Department of Obstetrics, Gynecology and Reproductive Sciences at UM SOM.

Neural tube defects occur when misfolded proteins accumulate in the cells of the developing nervous system. The misfolded proteins form insoluble clumps, known as aggregates, which cause widespread cell death, eventually leading to birth defects. Protein aggregates also play a major role in Alzheimer鈥檚, Parkinson鈥檚 and Huntington鈥檚 disease. In Alzheimer鈥檚, for instance, this leads to the accumulation of plaques in the brain, reducing the ability of that organ to function.

The researchers studied pregnant mice with diabetes, and found that their embryos contained aggregates of at least three misfolded proteins that are also associated with the three neurodegenerative diseases: 伪-Synuclein, Parkin, and Huntingtin. It is not clear exactly how these protein aggregates contribute to those diseases, but the link is well established.

This latest research also underscores the links between diabetes and some neurodegenerative diseases. People with diabetes have a higher risk of Alzheimer鈥檚 and Parkinson鈥檚 disease, and some research suggests that there are molecular links between Huntington鈥檚 and diabetes as well.

The scientists also examined whether it is possible to reduce levels of the misfolded proteins, and in so doing reduce neural tube defects. They gave diabetic pregnant animals sodium 4-phenylbutyrate (PBA), a compound that can reduce mistakes in molecular structure by aiding the molecules that ensure proper protein folding. In the animals that received PBA, there was significantly less protein misfolding, and fewer neural tube defects in the embryos. PBA has already been approved by the US Food and Drug Administration for other uses, and if it proves safe and effective in humans for this purpose, it could potentially reach patients much more quickly than an entirely new drug.

Neural tube defects are birth defects of the brain and spinal cord. They occur in the first month of pregnancy. The two most common are spina bifida and anencephaly. In the first, the fetal spinal column doesn't close completely. This usually causes nerve damage, with some paralysis of the legs. In the latter, most of the brain and skull do not develop. Infants with this defect are usually stillborn or die soon after birth. Neural tube defects have several causes, including diabetes, folic acid deficiency, obesity in the mother, and consumption of certain medications. About 10 percent of women with diabetes who are pregnant will have embryos with neural tube defects.

鈥淭his research makes clear that there is often a direct connection between 鈥渂asic鈥� scientific research and clinical progress,鈥� said Dean Reece, who is also the vice president for Medical Affairs, University of Maryland, and the John Z. and Akiko K. Bowers Distinguished Professor. 鈥淥ur goal with this work is not only to better understand diabetes in neurodegenerative disease, but to find more effective ways to help patients who suffer from these complex and difficult illnesses.鈥�

About the University of Maryland School of BOB体育

Celebrating its 210th Anniversary, the University of Maryland School of BOB体育 was chartered in 1807 and is the first public medical school in the United States and continues today as an innovative leader in accelerating innovation and discovery in medicine. The School of BOB体育 is the founding school of the University of Maryland and is an integral part of the 11-campus University System of Maryland. Located on the University of Maryland鈥檚 Baltimore campus, the School of BOB体育 works closely with the University of Maryland Medical Center and Medical System to provide a research-intensive, academic and clinically based education. With 43 academic departments, centers and institutes and a faculty of more than 3,000 physicians and research scientists plus more than $400 million in extramural funding, the School is regarded as one of the leading biomedical research institutions in the U.S. with top-tier faculty and programs in cancer, brain science, surgery and transplantation, trauma and emergency medicine, vaccine development and human genomics, among other centers of excellence. The School is not only concerned with the health of the citizens of Maryland and the nation, but also has a global presence, with research and treatment facilities in more than 35 countries around the world.

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鈥�&苍产蝉辫;

鈥�&苍产蝉辫;Department of Obstetrics, Gynecology and Reproductive Sciences